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Mélodie Labarchède

Physiological membrane dynamics of oligodendrocytes

mai 2023 Directeur(s) de thèse : Arne Battefeld Résumé de thèse

Oligodendrocytes are the glial cells of the central nervous system that generate myelin sheaths around neuronal axons in vertebrates. Myelin accelerates the conduction speed of neuronal transmission generating saltating action potential across internodes all along axons. Recent studies showed the existence of a periaxonal space playing a role in myelin electrical conduction that participate in saltatory transmission. During an action potential large potassium changes occur at the nodes of Ranvier. Potassium outflow via neuronal potassium channels under the myelin, repolarizes the axon. While potassium uptake has been shown at the cell body of oligodendrocytes the uptake at myelinating internodes has not been demonstrated. Additionally, very little is known about the spatial dynamics of ion flow in oligodendrocyte internodes. In this project, the aim is to address the spatial distribution of ion dynamics in oligodendrocytes and their processes.

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