Research subject

Our research team aims to understand the molecular and cellular mechanisms responsible for the brain degeneration in proteinopathies and (ii) the subsequent symptoms in these same diseases. Three proteins receive our attention: alpha-synuclein, Tau and TDP-43.

Our research is developed around different axes:

  • Biophysics of amyloid polymorphs.

This axis proposes to study the structure-activity relationship of amyloids using numerous biochemical and biophysical tools applied to synthetic assemblies and brain extracts from patients, but also based on in vitro models based on primary neuronal and glial cultures. These analytical and functional approaches aim at deciphering the cascade of events linking amyloid aggregation to neurodegeneration and at identifying molecular targets for the development of neuroprotective approaches.

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  • Modeling proteinopathies

This line of research, conducted in vivo, will allow us to study (i) the mechanistic of the induced degeneration and (ii) the pathophysiological consequences (behaviour, electrophysiology, neurochemistry, anatomo-pathology) through the administration of aggregated proteins in rodents and non-human primates. The specific role of the extra-cellular space in the propagation of aggregative information is particularly highlighted.

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  • Physiopathology of autophagic dysfunctions

These proteinopathies are all accompanied by autophagy dysfunctions (autophagic lysosomal pathway, macroautophagy, mitophagy, chaperone-mediated autophagy). Based on pathophysiological investigations, this axis aims to develop innovative therapeutic approaches (nanotechnology, gene therapy) for these different pathways in proteinopathies.

2023_T01_Fig04

  • Therapeutics for disease symptoms

Our history includes, in collaboration with the Centre Hospitalier Régional Universitaire de Bordeaux, a translational approach in the field of neurodegenerative diseases oriented towards disease management and medical applications. We aim to identify new therapeutic targets for specific symptoms through pathophysiological studies in experimental models and humans.

 

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Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 207.

titre
Une neuroprothèse spinale contre les déficits locomoteurs de la maladie de Parkinson
auteur
Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
article
Médecine/Sciences, 2024, 40 (1), pp.104-106. ⟨10.1051/medsci/2023185⟩
identifiant
hal-04433409
titre
Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
auteur
Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José Obeso, Erwan Bezard, Benjamin Dehay
article
npj Parkinson's Disease, 2023, 9 (1), pp.135. ⟨10.1038/s41531-023-00579-w⟩
identifiant
inserm-04211861
titre
A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease
auteur
Tomislav Milekovic, Eduardo Martin Moraud, Nicolo Macellari, Charlotte Moerman, Flavio Raschellà, Shiqi Sun, Matthew G Perich, Camille Varescon, Robin Demesmaeker, Alice Bruel, Léa N Bole-Feysot, Giuseppe Schiavone, Elvira Pirondini, Cheng Yunlong, Li Hao, Andrea Galvez, Sergio Daniel Hernandez-Charpak, Gregory Dumont, Jimmy Ravier, Camille G Le Goff-Mignardot, Jean-Baptiste Mignardot, Gaia Carparelli, Cathal Harte, Nicolas Hankov, Viviana Aureli, Anne Watrin, Hendrik Lambert, David Borton, Jean Laurens, Isabelle Vollenweider, Simon Borgognon, François Bourre, Michel Goillandeau, Wai Kin D Ko, Laurent Petit, Qin Li, Rik Buschman, Nicholas Buse, Maria Yaroshinsky, Jean-Baptiste Ledoux, Fabio Becce, Mayté Castro Jimenez, Julien F Bally, Timothy Denison, Dominique Guehl, Auke Ijspeert, Marco Capogrosso, Jordan W Squair, Leonie Asboth, Philip A Starr, Doris D Wang, Stéphanie P Lacour, Silvestro Micera, Chuan Qin, Jocelyne Bloch, Erwan Bezard, G Courtine
article
Nature Medicine, 2023, ⟨10.1038/s41591-023-02584-1⟩
identifiant
hal-04279036
titre
GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
auteur
Miguel Lopez-Cuina, Paul Guérin, Nathalie Dutheil, Christelle Martin, Thierry Leste Lasserre, Pierre‐olivier Fernagut, Wassilios Meissner, Erwan Bezard
article
Movement Disorders, 2023, 38 (7), pp.1336-1340. ⟨10.1002/mds.29422⟩
identifiant
hal-04234640
titre
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
auteur
Audrey Fayard, Alexis Fenyi, Sonia Lavisse, Sandra Dovero, Luc Bousset, Tracy Bellande, Sophie Lecourtois, Christophe Jouy, Martine Guillermier, Caroline Jan, Pauline Gipchtein, Benjamin Dehay, Erwan Bezard, Ronald Melki, Philippe Hantraye, Romina Aron Badin
article
Neurobiology of Disease, 2023, 180, pp.106086. ⟨10.1016/j.nbd.2023.106086⟩
identifiant
inserm-04033469