Research subject

Our research project aims to better understand the pathophysiology of Parkinson’s disease in order to improve the existing therapeutic approaches and to develop new therapies for the disease. Currently, we especially focus our work on the role of monoaminergic systems in the pathophysiology and therapy of Parkinson’s disease.

Nowadays, motors symptoms of Parkinson’s disease are better defined. We have recently shown the implication of monoamine depletion (noradrenaline, dopamine, serotonin) in the development of motor and non-motor deficits. The issue is now to study more precisely the role of the monoaminergic systems in the pathophysiology and treatments of Parkinson’s disease. Thus, we are working on five topics linked to this thematic:

  • Effects of combined monoamine cell degeneration on motor and non-motor functions.
  • Effects of combined monoamine cell degeneration on the neuronal activity of brain structures involved in motor and non-motor functions.
  • Impact of Noradrenaline and serotonin depletions on the therapeutic efficacy of anti-parkinsonian treatments.
  • Mechanisms of the deep brain stimulation of the subthalamic nucleus induced obesity (in collaboration with Daniela Cotta, Neurocentre Magendie, Bordeaux University).
  • Physiopathological study of alpha-synuclein model in rats : behavior, neurochemistry and electrophysiology.

L-DOPA is currently a reference treatment of Parkinson’s disease, but its effects are not well understood. Thanks to a neurochemical analysis, we are studying the mechanisms of action of this molecule in order to better understand its positive and negative effects. We are developing three topics:

  • Study of the mechanism of action of L-DOPA in-depth: role of serotonergic neurons and possible serotonergic strategies for ameliorating L-DOPA therapy.
  • Study of the action of L-DOPA on the activity of the basal ganglia.
  • Study of incorporation of L-DOPA into proteins.

Research axes

  • Study of the link between subthalamic nucleus oscillations and motor deficits.
  • Investigation of the consequences of monoamine modulation (dopamine, noradrenaline and serotonin) on motor and non-motor behaviors and on the neuronal activity of different brain structures implicated in these behaviors.
  • Study of the neurochemical consequences of L-Dopa and high frequency stimulation of the subthalamic nucleus in the context of Parkinson’s disease.

 

Complete bibliography >>>

Latest publications

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Criteria : Author : "Abdelhamid,Benazzouz; Philippe, De deurwaerdere", Publication type : "('ART')"
Number of occurrences founded : 39.

titre
Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models
auteur
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc Do Rego, Jean-Claude Do Rego, Frédéric Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltête, Abdelhamid Benazzouz, Catherine Baugé, Jérôme Leprince, Abdel Elkahloun, Lee Eiden, Youssef Anouar
article
Redox Biology, Elsevier, 2021, 40, pp.101839. ⟨10.1016/j.redox.2020.101839⟩
identifiant
hal-03132187
titre
In vivo validation of a new portable stimulator for chronic deep brain stimulation in freely moving rats
auteur
Houyam Tibar, Frédéric Naudet, Florian Kolbl, Bastien Ribot, Emilie Faggiani, Gilles N’kaoua, Sylvie Renaud, Noëlle Lewis, Abdelhamid Benazzouz
article
Journal of Neuroscience Methods, Elsevier, 2020, 333, pp.108577. ⟨10.1016/j.jneumeth.2019.108577⟩
identifiant
hal-02469071
titre
Molecular Sciences Review Serotonin in Animal Cognition and Behavior
auteur
Julien Bacqué-Cazenave, Rahul Bharatiya, Grégory Barrière, Jean-Paul Delbecque, Nouhaila Bouguiyoud, Giuseppe Giovanni, Daniel Cattaert, Philippe de Deurwaerdère
article
International Journal of Molecular Sciences, MDPI, 2020, 21 (5), pp.1649. ⟨10.3390/ijms21051649⟩
identifiant
hal-02975112
titre
Early neurochemical modifications of monoaminergic systems in the R6/1 mouse model of Huntington's disease
auteur
Emilie Puginier, Rahul Bharatiya, Abdeslam Chagraoui, Julien Manem, Yoon Cho, Maurice Garret, Philippe de Deurwaerdère
article
Neurochemistry International, Elsevier, 2019, 128, pp.186-195. ⟨10.1016/j.neuint.2019.05.001⟩
identifiant
hal-02362066
titre
Molecular Sciences L-DOPA in Parkinson's Disease: Looking at the "False" Neurotransmitters and Their Meaning
auteur
Abdeslam Chagraoui, Marie Boulain, Laurent Juvin, Youssef Anouar, Grégory Barrière, Philippe de Deurwaerdère
article
International Journal of Molecular Sciences, MDPI, 2019, 21 (1), pp.294. ⟨10.3390/ijms21010294⟩
identifiant
hal-02975109