Research subject

Motion and emotion are intimately linked. The major goal of our research is to delineate the functions of dopamine in the “extended basal ganglia network” (EBG). EBG is a neural circuit controlling movement and emotional states (voluntary movement, associative learning, explorative behavior using processing of relevant sensory information, stress), but is also involved in neurological and psychiatric disorders (Parkinson’s disease, Huntington’s disease, anxiety). The objective of our team is to establish a base of knowledge to define therapeutic avenues to treat the symptoms of neurological and psychiatric diseases related to the dopaminergic system. We are particularly interested in the control of synaptic transmission and plasticity by dopamine.

We study these mechanisms at the synapse, cell, neuronal circuit and behavioral levels. We combine state-of-the-art technology, such as: in and ex vivo electrophysiology (coupled with cell identification after single cell labeling), intersectional viral approaches to identify (tracing), manipulate (optogenetics, chemogenetics) and record (endoscopic imaging & fiberphotometry) neuronal activity (calcium imaging) or dopamine release (dopamine sensor) in animals engaged in a behavioral task. Using those innovative neurotechniques we aim to uncover how defined subsets of neurons within the EBG encode aspects of motion and emotion.

 

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Criteria : Author : "Jerome,Baufreton; François,Georges", Publication type : "('ART')"
Number of occurrences founded : 78.

titre
Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus
auteur
Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent
article
Current Neuropharmacology, In press, 22 (9), pp.1528-1539. ⟨10.2174/1570159X21666230720121027⟩
identifiant
hal-04181821
titre
A role for the subthalamic nucleus in aversive learning
auteur
Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
article
Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
identifiant
hal-04273150
titre
A role for the subthalamic nucleus in aversive learning
auteur
Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
article
Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
identifiant
hal-04272062
titre
Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization
auteur
Yamuna Mariani, Ana Covelo, Rui S Rodrigues, Francisca Julio-Kalajzić, Antonio C Pagano Zottola, Gianluca Lavanco, Michela Fabrizio, Doriane Gisquet, Filippo Drago, Astrid Cannich, Jerome Baufreton, Giovanni Marsicano, Luigi Bellocchio
article
Current Biology - CB, In press, ⟨10.1016/j.cub.2023.09.075⟩
identifiant
hal-04272298
titre
Emotion in action: When emotions meet motor circuits
auteur
Anaelle Braine, François Georges
article
Neuroscience and Biobehavioral Reviews, 2023, 155, pp.105475. ⟨10.1016/j.neubiorev.2023.105475⟩
identifiant
hal-04311811