Research subject

Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.

The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.

The research activities of the team evolve around the following axes :

  • Mechanisms of cell death in parkinsonian syndromes

Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.

  • Decrypting brain pathophysiology using innovative optical nanoprobes

Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.

  • Pathophysiology of L-dopa-induced dyskinesia

Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.

  • Purinergic signalling in the central nervous system

Our overall goal is to better understand the regulation and function of ATP signaling in the central nervous system. We will determine the spatiotemporal profile of ATP actions as well as the profile of expression of purine receptor during both neurogenesis and in pathological states.

Research axes

  • Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
  • Study of targeting autophagy as a potential cure of Parkinson’s disease.
  • Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
  • Improvement of transgenesis approaches in neurodegenerative diseases modelling.
  • Study of the role of extracellular space in neuronal communication.

 

Complete bibliography >>>

Latest publications

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Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 170.

titre
Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
auteur
Eléonore Bertin, Thomas Deluc, Kjara Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bézard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine Bertrand, Olivier Nicole, Eric Boué-Grabot
article
Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-019-0641-8⟩
identifiant
hal-02438455
titre
Intrastriatal injection of alpha-synuclein fibrils induces Parkinson-like pathology in macaques
auteur
Benjamin Dehay, Erwan Bézard
article
Brain - A Journal of Neurology , Oxford University Press (OUP), 2019, 142 (11), pp.3321-3322. ⟨10.1093/brain/awz329⟩
identifiant
inserm-02439514
titre
Multiple System Atrophy: Recent Developments and Future Perspectives
auteur
Wassilios Meissner, Pierre‐olivier Fernagut, Benjamin Dehay, Patrice Péran, Anne Pavy‐le Traon, Alexandra Foubert‐samier, Miguel Lopez Cuina, Erwan Bézard, François Tison, Olivier Rascol
article
Movement Disorders, Wiley, 2019, 34 (11), pp.1629-1642. ⟨10.1002/mds.27894⟩
identifiant
inserm-02439518
titre
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
auteur
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios Meissner, Erwan Bézard, Benjamin Dehay
article
JCI Insight, American Society for Clinical Investigation, 2019, 4 (16), pii: 129719. ⟨10.1172/jci.insight.129719⟩
identifiant
inserm-02439504
titre
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
auteur
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios Meissner, Erwan Bezard, Benjamin Dehay
article
JCI Insight, American Society for Clinical Investigation, 2019
identifiant
hal-02346929