Research subject

Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.

The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.

The research activities of the team evolve around the following axes :

  • Mechanisms of cell death in parkinsonian syndromes

Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.

  • Decrypting brain pathophysiology using innovative optical nanoprobes

Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.

  • Pathophysiology of L-dopa-induced dyskinesia

Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.

  • Purinergic signalling in the central nervous system

Our overall goal is to better understand the regulation and function of ATP signaling in the central nervous system. We will determine the spatiotemporal profile of ATP actions as well as the profile of expression of purine receptor during both neurogenesis and in pathological states.

Research axes

  • Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
  • Study of targeting autophagy as a potential cure of Parkinson’s disease.
  • Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
  • Improvement of transgenesis approaches in neurodegenerative diseases modelling.
  • Study of the role of extracellular space in neuronal communication.

 

Complete bibliography >>>

Latest publications

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Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 195.

titre
Evaluation of blood flow as a route for propagation in experimental synucleinopathy
auteur
Xuan Yu, Marine Persillet, Ling Zhang, Yu Zhang, Sun Xiuping, Xianglei Li, Gao Ran, Ludivine Breger, Sandra Dovero, Gregory Porras, Benjamin Dehay, Erwan Bezard, Chuan Qin
article
Neurobiology of Disease, Elsevier, 2021, pp.105255. ⟨10.1016/j.nbd.2021.105255⟩
identifiant
inserm-03105389
titre
L‐DOPA regulates α‐synuclein accumulation in experimental parkinsonism
auteur
Marc Deffains, Marie‐hélène Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre‐olivier Fernagut
article
Neuropathology and Applied Neurobiology, Wiley, 2020, Online ahead of print. ⟨10.1111/nan.12678⟩
identifiant
inserm-03054308
titre
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
auteur
Federico Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bézard
article
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3440. ⟨10.1038/s41467-020-17328-9⟩
identifiant
inserm-02904850
titre
Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
auteur
Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios Meissner, Erwan Bezard, Francesca de Giorgi, François Ichas
article
Cells, MDPI, 2020, 9 (11), pp.2371. ⟨10.3390/cells9112371⟩
identifiant
hal-03012542
titre
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
auteur
Francesca de Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
article
Science Advances , American Association for the Advancement of Science (AAAS), 2020, 6 (40), pp.eabc4364. ⟨10.1126/sciadv.abc4364⟩
identifiant
hal-02964382