Team 1
Pathophysiology of proteinopathies (page under construction)
AROTCARENA Marie-Laure (Engineer) CANRON Marie-Hélène (Engineer) CORDOVADO Amélie (Engineer) CULERIR Elodie (Engineer GPR) DARRICAU Morgane (PhD student) DE GIORGI-ICHAS Francesca (INSERM Researcher) DEHAY Benjamin (INSERM Research Director) DOUDNIKOFF Evelyne (Engineer) ESTAUN-PANZANO Juan (PhD student) ICHAS François (INSERM Research Director) KASHYRINA Marianna (Post-doc) KINET Rémi (PhD student) LAFERRIERE Florent (CNRS Researcher) LANCELIN Camille (Engineer GPR) LETOURNEUR Aenora (PhD student) MARTIN-NEGRIER Marie-Laure (Physician/Researcher) MAZZOCCO Claire (Engineer) PIQUEMAL-LAGOUEILLAT Marion (Engineer) PLANCHE Vincent (Physician/Researcher) PRUDON Nicolas (PhD student) SABATIER Ludivine (PhD student) THIOLAT Marie-Laure (Assistant-engineer)
Research subject
Our research team aims to understand the molecular and cellular mechanisms responsible for the brain degeneration in proteinopathies and (ii) the subsequent symptoms in these same diseases. Three proteins receive our attention: alpha-synuclein, Tau and TDP-43.
Our research is developed around different axes:
- Biophysics of amyloid polymorphs.
This axis proposes to study the structure-activity relationship of amyloids using numerous biochemical and biophysical tools applied to synthetic assemblies and brain extracts from patients, but also based on in vitro models based on primary neuronal and glial cultures. These analytical and functional approaches aim at deciphering the cascade of events linking amyloid aggregation to neurodegeneration and at identifying molecular targets for the development of neuroprotective approaches.
- Modeling proteinopathies
This line of research, conducted in vivo, will allow us to study (i) the mechanistic of the induced degeneration and (ii) the pathophysiological consequences (behaviour, electrophysiology, neurochemistry, anatomo-pathology) through the administration of aggregated proteins in rodents and non-human primates. The specific role of the extra-cellular space in the propagation of aggregative information is particularly highlighted.
- Physiopathology of autophagic dysfunctions
These proteinopathies are all accompanied by autophagy dysfunctions (autophagic lysosomal pathway, macroautophagy, mitophagy, chaperone-mediated autophagy). Based on pathophysiological investigations, this axis aims to develop innovative therapeutic approaches (nanotechnology, gene therapy) for these different pathways in proteinopathies.
- Therapeutics for disease symptoms
Our history includes, in collaboration with the Centre Hospitalier Régional Universitaire de Bordeaux, a translational approach in the field of neurodegenerative diseases oriented towards disease management and medical applications. We aim to identify new therapeutic targets for specific symptoms through pathophysiological studies in experimental models and humans.
Latest publications
Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 203.
- titre
- Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
- auteur
- Audrey Fayard, Alexis Fenyi, Sonia Lavisse, Sandra Dovero, Luc Bousset, Tracy Bellande, Sophie Lecourtois, Christophe Jouy, Martine Guillermier, Caroline Jan, Pauline Gipchtein, Benjamin Dehay, Erwan Bezard, Ronald Melki, Philippe Hantraye, Romina Aron Badin
- article
- Neurobiology of Disease, 2023, 180, pp.106086. ⟨10.1016/j.nbd.2023.106086⟩
- identifiant
- inserm-04033469
- titre
- Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
- auteur
- Morgane Darricau, Taxiarchis Katsinelos, Flavio Raschella, Tomislav Milekovic, Louis Crochemore, Qin Li, Grégoire Courtine, William Mcewan, Benjamin Dehay, Erwan Bezard, Vincent Planche
- article
- Brain - A Journal of Neurology , 2022, pp.awac428. ⟨10.1093/brain/awac428⟩
- identifiant
- inserm-03891736
- titre
- The Zinc Ionophore Clioquinol Reduces Parkinson’s Disease Patient-Derived Brain Extracts-Induced Neurodegeneration
- auteur
- Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Dehay
- article
- Molecular Neurobiology, 2022, Online ahead of print. ⟨10.1007/s12035-022-02974-5⟩
- identifiant
- inserm-03773965
- titre
- Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
- auteur
- Marie‐laure Arotcarena, Federico Soria, Anthony Cunha, Evelyne Doudnikoff, Geoffrey Prévot, Jonathan Daniel, Mireille Blanchard‐desce, Philippe Barthélémy, Erwan Bezard, Sylvie Crauste‐manciet, Benjamin Dehay
- article
- Aging Cell, 2022, pp.e13584. ⟨10.1111/acel.13584⟩
- identifiant
- inserm-03617988
- titre
- Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
- auteur
- Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios Meissner, María Trinidad Herrero, Miquel Vila, Jose Obeso, Erwan Bezard, Benjamin Dehay
- article
- Brain - A Journal of Neurology , 2022, Online ahead of print. ⟨10.1093/brain/awab374⟩
- identifiant
- inserm-03609490