Research subject

Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.

The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.

The research activities of the team evolve around the following axes :

  • Mechanisms of cell death in parkinsonian syndromes

Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.

  • Decrypting brain pathophysiology using innovative optical nanoprobes

Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.

  • Pathophysiology of L-dopa-induced dyskinesia

Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.

  • Purinergic signalling in the central nervous system

Our overall goal is to better understand the regulation and function of ATP signaling in the central nervous system. We will determine the spatiotemporal profile of ATP actions as well as the profile of expression of purine receptor during both neurogenesis and in pathological states.

Research axes

  • Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
  • Study of targeting autophagy as a potential cure of Parkinson’s disease.
  • Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
  • Improvement of transgenesis approaches in neurodegenerative diseases modelling.
  • Study of the role of extracellular space in neuronal communication.

 

Complete bibliography >>>

Latest publications

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Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 122.

titre
Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism
auteur
Jérôme Baufreton, Tomislav Li, Qin Li, Steve Mcguire, Eduardo Martin Moraud, Gregory Porras, Shiqi Sun, Wai Kin D. Ko, Marine Chazalon, Stéphanie Morin, Elisabeth Normand, Géraldine Farjot, Aude Milet, Jan Pype, Elsa Pioli, Grégoire Courtine, Baptiste Bessière, Erwan Bezard
article
Movement Disorders, Wiley, 2018, 〈10.1002/mds.27404〉
identifiant
hal-01797158
titre
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.
auteur
Fares Bassil, Paul A Guerin, Nathalie Dutheil, Qin Li, Matthias Klugmann, Wassilios G Meissner, Erwan Bezard, Pierre-Olivier Fernagut
article
Movement Disorders, Wiley, 2017, 〈10.1002/mds.27041〉
identifiant
hal-01537940
titre
Involvement of the bed nucleus of the stria terminalis in L-Dopa induced dyskinesia.
auteur
Matthieu F Bastide, Christelle Glangetas, Evelyne Doudnikoff, Qin Li, Mathieu Bourdenx, Pierre-Olivier Fernagut, Éric C Dumont, François Georges, Erwan Bézard
article
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.2348. 〈10.1038/s41598-017-02572-9〉
identifiant
hal-01537926
titre
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration.
auteur
Federico N Soria, Michel Engeln, Marta Martinez-Vicente, Christelle Glangetas, Sandra Dovero, Benjamin Dehay, Elisabeth Normand, Miquel Vila, Alexandre Favereaux, François Georges, Christophe Lo Bianco, Erwan Bezard, Pierre-Olivier Fernagut, María José López-González
article
Human Molecular Genetics, Oxford University Press (OUP), 2017, 〈10.1093/hmg/ddx120〉
identifiant
hal-01537890
titre
U18666A, an Activator of Sterol Regulatory Element Binding Protein (SREBP) Pathway Modulates Presynaptic Dopaminergic Phenotype of SH-SY5Y Neuroblastoma Cells.
auteur
Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F Javier Garcia-Ladona
article
Synapse, Wiley-Blackwell, 2017, 〈10.1002/syn.21980〉
identifiant
hal-01537444