Research subject

Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.

The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.

The research activities of the team evolve around the following axes :

  • Mechanisms of cell death in parkinsonian syndromes

Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.

  • Decrypting brain pathophysiology using innovative optical nanoprobes

Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.

  • Pathophysiology of L-dopa-induced dyskinesia

Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.

  • Purinergic signalling in the central nervous system

Our overall goal is to better understand the regulation and function of ATP signaling in the central nervous system. We will determine the spatiotemporal profile of ATP actions as well as the profile of expression of purine receptor during both neurogenesis and in pathological states.

Research axes

  • Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
  • Study of targeting autophagy as a potential cure of Parkinson’s disease.
  • Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
  • Improvement of transgenesis approaches in neurodegenerative diseases modelling.
  • Study of the role of extracellular space in neuronal communication.

 

Complete bibliography >>>

Latest publications

Search Results --> Url version détaillée , Url version formatée
Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 132.

titre
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
auteur
Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios Meissner, Erwan Bezard, Benjamin Dehay
article
JCI Insight, American Society for Clinical Investigation, 2019
identifiant
hal-02346929
titre
l ‐Dopa–free learned dyskinetic behavior in a Parkinson's primate model
auteur
Pierre-Olivier Fernagut, Qin Li, Erwan Bezard
article
Movement Disorders, Wiley, 2019, 34 (8), pp.1237-1237. ⟨10.1002/mds.27715⟩
identifiant
hal-02346960
titre
Engrailed‐1 induces long‐lasting behavior benefit in an experimental Parkinson primate model
auteur
Nitza Thomasson, Elsa Pioli, Claire Friedel, Arnaud Monseur, Jérémie Lavaur, Kenneth Moya, Erwan Bezard, Anne Bousseau, Alain Prochiantz
article
Movement Disorders, Wiley, 2019, 34 (7), pp.1082-1084. ⟨10.1002/mds.27714⟩
identifiant
hal-02380250
titre
Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
auteur
Chiara Paviolo, Federico Soria, Joana Ferreira, Antony Lee, Laurent Groc, Erwan Bezard, Laurent Cognet
article
Methods, Elsevier, 2019, ⟨10.1016/j.ymeth.2019.03.005⟩
identifiant
hal-02347789
titre
Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism
auteur
Jérôme Baufreton, Tomislav Milekovic, Qin Li, Steve Mcguire, Eduardo Martin Moraud, Gregory Porras, Shiqi Sun, Wai Kin D. Ko, Marine Chazalon, Stephanie Morin, Elisabeth Normand, Géraldine Farjot, Aude Milet, Jan Pype, Elsa Pioli, Grégoire Courtine, Baptiste Bessière, Erwan Bezard
article
Movement Disorders, Wiley, 2018, 33 (10), pp.1632-1642. ⟨10.1002/mds.27404⟩
identifiant
hal-02275286