Team 1
Pathophysiology of parkinsonian syndromes
AROTCARENA Marie-Laure (engineer) BEZARD Erwan (researcher) BOURRE François (researcher) CANRON Marie-Hélène ( engineer) CUNHA Anthony (PhD student) DARRICAU Morgane (PhD student) DE GIORGI-ICHAS Francesca (researcher) DEHAY Benjamin (researcher) DELAMARRE Anna (PhD student) DOUDNIKOFF Marie-Evelyne (engineer) ESTAUN-PANZANO Juan (PhD student) ICHAS François (researcher) LAFERRIERE Florent (researcher) MARTIN-NEGRIER Marie-Laure (physician/researcher) MAZZOCCO Claire (engineer) MEISSNER Wassilios (physician/researcher) MOLE Angelina (PhD student) PLANCHE Vincent (physician/assistant researcher) PRUDON NIcolas (PhD student) SIKORA Joanna (post-doc) THIOLAT Marie-Laure (technician) TEIL Margaux (post-doc)
Research subject
Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.
The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.
The research activities of the team evolve around the following axes :
- Mechanisms of cell death in parkinsonian syndromes
Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.
- Decrypting brain pathophysiology using innovative optical nanoprobes
Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.
- Pathophysiology of L-dopa-induced dyskinesia
Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.
Research axes
- Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
- Study of targeting autophagy as a potential cure of Parkinson’s disease.
- Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
- Improvement of transgenesis approaches in neurodegenerative diseases modelling.
- Study of the role of extracellular space in neuronal communication.
Latest publications
Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 198.
- titre
- The Zinc Ionophore Clioquinol Reduces Parkinson’s Disease Patient-Derived Brain Extracts-Induced Neurodegeneration
- auteur
- Margaux Teil, Evelyne Doudnikoff, Marie-Laure Thiolat, Sylvain Bohic, Erwan Bezard, Benjamin Dehay
- article
- Molecular Neurobiology, Humana Press, 2022, Online ahead of print. ⟨10.1007/s12035-022-02974-5⟩
- identifiant
- inserm-03773965
- titre
- Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
- auteur
- Marie‐laure Arotcarena, Federico Soria, Anthony Cunha, Evelyne Doudnikoff, Geoffrey Prévot, Jonathan Daniel, Mireille Blanchard‐desce, Philippe Barthélémy, Erwan Bezard, Sylvie Crauste‐manciet, Benjamin Dehay
- article
- Aging Cell, Wiley Open Access, 2022, pp.e13584. ⟨10.1111/acel.13584⟩
- identifiant
- inserm-03617988
- titre
- Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
- auteur
- Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios Meissner, María Trinidad Herrero, Miquel Vila, Jose Obeso, Erwan Bezard, Benjamin Dehay
- article
- Brain - A Journal of Neurology , Oxford University Press (OUP), 2022, Online ahead of print. ⟨10.1093/brain/awab374⟩
- identifiant
- inserm-03609490
- titre
- Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
- auteur
- Francesca de Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco de Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, Francois Ichas
- article
- Biomolecules, MDPI, 2022, 12 (3), pp.436. ⟨10.3390/biom12030436⟩
- identifiant
- hal-03628777
- titre
- Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease
- auteur
- Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca de Giorgi, François Ichas
- article
- npj Parkinson's Disease, Nature, 2022, 8 (1), pp.10. ⟨10.1038/s41531-021-00264-w⟩
- identifiant
- hal-03763104