Research subject

Our goal is to understand molecular and cellular mechanisms responsible for motor and non-motor symptoms in Parkinson’s disease and atypical parkinsonism as well as the disturbed response to L-dopa. Our goal is thus to identify novel therapeutic targets on the ground of pathophysiological studies in experimental models (ranging from cell culture to non-human primate) as well as in man.

The cell death mechanisms and the pathological response to dopamine replacement therapies in parkinsonian syndromes are at the center of our research work. I close connection with the University Hospital of Bordeaux, we develop a translational research in the field of neurodegenerative disorders, oriented towards disease management and medical applications.

The research activities of the team evolve around the following axes :

  • Mechanisms of cell death in parkinsonian syndromes

Parkinson’s disease is characterized by a progressive accumulation and propagation of a-synuclein likely responsible for their subsequent death. Our objective is to understand these mechanisms for then proposing adapted therapeutic approaches.

  • Decrypting brain pathophysiology using innovative optical nanoprobes

Understanding the role of the extracellular space (ECS) in modulating neuronal communication represents a knowledge frontier in current brain research. We aim to decrypt the intimate interplay between extracellular space and receptors in shaping neuronal network (dys)function. To reach our goal we use innovative multidisciplinary approaches based on new optical nanoimaging reporters and tailored methodologies for manipulating brain functions in state-of-the-art Alzheimer’s disease and Parkinson’s disease models.

  • Pathophysiology of L-dopa-induced dyskinesia

Our 15 years of work now culminate with a series of clinical trials testing the efficacy of pharmacological and non-pharmacological approaches upon dyskinesia severity.

  • Purinergic signalling in the central nervous system

Our overall goal is to better understand the regulation and function of ATP signaling in the central nervous system. We will determine the spatiotemporal profile of ATP actions as well as the profile of expression of purine receptor during both neurogenesis and in pathological states.

Research axes

  • Modelling prion-like dissemination of synucleinopathies and tauopathies in nervous system in Parkinsonian syndromes and dementias.
  • Study of targeting autophagy as a potential cure of Parkinson’s disease.
  • Study of key mechanisms contributing to α-synuclein accumulation to counteract Parkinson’s disease and Multiple System Atrophy progression.
  • Improvement of transgenesis approaches in neurodegenerative diseases modelling.
  • Study of the role of extracellular space in neuronal communication.

 

Complete bibliography >>>

Latest publications

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Criteria : Author : "Bezard", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 183.

titre
Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia
auteur
Lauren Malave, Dustin Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas Kottmann
article
Communications Biology, Nature Publishing Group, 2021, 4 (1071), ⟨10.1038/s42003-021-02567-3⟩
identifiant
inserm-03352257
titre
Lack of Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment
auteur
Morgane Darricau, Marie-Hélène Canron, Marion Bosc, Marie-Laure Arotçarena, Mégane Le Quang, Benjamin Dehay, Erwan Bezard, Vincent Planche
article
Neurobiology of Aging, Elsevier, 2021, ⟨10.1016/j.neurobiolaging.2021.07.009⟩
identifiant
inserm-03297050
titre
Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
auteur
Eléonore Bertin, Thomas Deluc, Kjara Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bézard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine Bertrand, Olivier Nicole, Eric Boué-Grabot
article
Molecular Psychiatry, Nature Publishing Group, 2021, 26 (2), 629-644 Epub 2020 Jan 8. ⟨10.1038/s41380-019-0641-8⟩
identifiant
hal-02438455
titre
Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
auteur
Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin
article
Heliyon, Elsevier 2021, 7 (2), pp.e06302. ⟨10.1016/j.heliyon.2021.e06302⟩
identifiant
inserm-03154753
titre
Involvement of Autophagy in Levodopa‐Induced Dyskinesia
auteur
Michael Feyder, Carina Plewnia, Ori Lieberman, Giada Spigolon, Alessandro Piccin, Lidia Urbina, Benjamin Dehay, Qin Li, Per Nilsson, Mikael Altun, Emanuela Santini, David Sulzer, Erwan Bezard, Anders Borgkvist, Gilberto Fisone
article
Movement Disorders, Wiley, 2021, Online ahead of print. ⟨10.1002/mds.28480⟩
identifiant
inserm-03114552