Research subject

Bidirectional neuron-glia interactions provide the framework for the organization of the brain. One type of glia cell, the oligodendrocyte is well known for the establishment of myelin sheaths around axons, the neuronal output structure. Myelin enables fast communication between neurons, but oligodendrocytes fulfill additional physiological functions which we only start to understand. Our research aims to address this knowledge gap by understanding the physiology of oligodendrocytes and their impact on neuronal communication and vice-versa. The focus of our research is on the single cell and micro-circuit level. We continue to address the involvement of oligodendrocyte in the regulation of extracellular potassium concentrations. We complement our work with anatomical analysis of neocortical oligodendrocyte organisation and morphology.

Alterations of oligodendrocytes are a common feature among several neurodegenerative diseases. By combining our knowledge of physiological oligodendrocyte function we address the functional impact of pathophysiological alterations of oligodendrocytes on neuron-oligodendrocyte communication in neurodegenerative disease models. To address our key questions, we combine state of the art methods that include electrophysiology, advanced cellular imaging, electron microscopy and genetic approaches.

Research axes

  • Implications of oligodendrocytes in regulating extracellular potassium levels
  • Anatomical and functional organization of neocortical oligodendrocyte lineage cells

Complete bibliography >>>

Latest publications

Search Results --> Url version détaillée , Url version formatée
Criteria : Author : "Arne,Battefeld;", Publication type : "('ART')"
Number of occurrences founded : 1.

The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling
Ana Dorrego-Rivas, Jerome Ezan, Maïté Moreau, Sonia Poirault-Chassac, Nathalie Aubailly, Julie de Neve, Camille Blanchard, Francis Castets, Amélie Fréal, Arne Battefeld, Nathalie Sans, Mireille Montcouquiol
Science Advances , American Association for the Advancement of Science (AAAS), 2022, 8 (36), ⟨10.1126/sciadv.abo6333⟩