Neurofunctional imaging group
BEAUDET Grégory (Engineer) BEGUEDOU Naka (Engineer) CREMONA Sandrine (Engineer) CRIVELLO Fabrice (Researcher) DELALANDE Christophe (Engineer) HESLING Isabelle (Assistant Professor) JOBARD Gaël (Assistant Professor) JOLIOT Marc (Researcher) LABACHE Loïc (PhD student) LAURENT Alexandre (Engineer) LEROUX Gaëlle (Engineer) MAINGAULT Sophie (Engineer) MAZOYER Bernard (Professor) MELLET Emmanuel (Researcher) PEPE Antonietta (Post-doc) PETIT Laurent (Researcher) TSUCHIDA Ami (Post-Doc) TZOURIO-MAZOYER Nathalie (Researcher) VERRECCHIA Violaine (PhD student) ZAGO Laure (Researcher)
We are a multidisciplinary research team gathering scientists from various domains: mathematics, medical imaging, nuclear medicine, signal processing, psychiatry and cognitive neurosciences. Our research attempts at understanding the cognitive, behavioural, genetic, and brain morphological/functional underpinnings of the human brain hemispheric specialization (HS).
Hemispheric specialization is a relationship between a cognitive function and a set of cerebral structures of a given hemisphere. It includes both the hosting of specialized networks that have unique functional properties and mechanisms that allow inter-hemispheric coordination necessary for effective cognitive processing. The observations of patients with brain lesions since that of Broca in 1860 showed that the peculiarity of the SH of Humans is its low variability. For example more than 90% of the human beings have language functions in the left hemisphere and visuo-spatial attention by the right hemisphere. Studies of people with developmental diseases that cause language abnormalities such as dysphasia or dyslexia have shown that these subjects are less asymmetrical at the brain level. This is also the case in certain psychoses such as schizophrenia. But the origin and the factors of variability the HS remains poorly known in part because of its low variability.
We work on neuroimaging cohorts of healthy volunteers in order:
1-to determine how the two hemispheres are differentially involved in a given task, how HS variability is associated with cognitive functioning and how gene shapes HS. To this aims, we have acquired the Brain Imaging of Lateralization by the BIL&GIN (Brain Imaging Lateralization & GIN) database of 453 healthy participants;
2- to characterize the neural support of the late maturational stages of healthy brain within the frame of the i-Share cohort of students’ health conducted by C Tzourio. We are currently acquiring brain anatomical and functional images in 2,000 students of Bordeaux University.
The GIN research activity revolves around five thematic axes :
- Exploring the rules for the setting up of the different hemispheric specializations.
- Hemispheric specialization and cognitive skills.
- Comparison of left and right hemispheres integrating anatomical, resting-state and task-induced related organization.
- Unmasking cognitive networks and their lateralization from intrinsic connectivity.
- Genetics of brain lateralization (Multiple collaborations with Dana, ENIGMA consortium; C Francks, MPI Nijmegen; Ml Carreiras, BCBL, San Sebastian; H Adams, Erasmus Univ. Rotterdam).
How does the hemispherical cerebral organization of cognitive functions take place? How does it happen that some people atypically shelter language in their right hemisphere? Is hemispheric lateralization necessary for optimal cerebral and cognitive functioning? If yes, for which functions? Are the subjects atypical for a given also have atypical organization of other cognitive networks? Are anatomical asymmetries markers of functional asymmetries? Can we determine non-invasively the lateralization for the language of an individual? Do atypical individuals have genetic features that explain their change in lateralization? To answer these questions we combine anatomical, functional neuroimaging, connectivity measures, behavioral data, genotyping and databasing.
A complete map of the cerebral connections, the connectome, is required for interpreting measurements of the signals transmitted between neurons. In the human brain, these signals travel in a complex network of 100 billion or so neurons, each of which is connected to 10,000 others, through the axons which constitute the bundles of white matter fibers. Identifying these pathways of connections is a first approach to establish such a map. Another approach, known as functional connectivity, is to follow the spontaneous activity synchronized between the groups of neurons.
The combination of these two approaches is possible thanks to the advances of both anatomical and functional Magnetic Resonance Imaging (MRI) technologies. Our project deals with this new framework of the modern neuroscience, the connectomics, which examines the anatomical organization and the functioning of the brain through the connectome to relate it with the cognitive functioning.
Population neuroimaging aims to identify the different potential sources of brain variability and to measure the size of their effects and their interaction. It is our area of research whose contributions are important from both cognitive, societal, and medical perspectives. Population neuroimaging has an important role to play in face of the many questions and preconceptions that give rise to particularly hot debates such as for example the relationship between brain and mind, the respective roles of genes and environment on the morphology, organization, functional architecture, and performances of our brains, whether or not a sexual brain exists, the differences between left-handers and right-handers, etc. Finally, from medical and healthcare perspectives, understanding what is at the source of cerebral variability and quantifying the limits of its “normality” are of course fundamental to progress on the definition, diagnosis and development of new therapeutic approaches to cerebral diseases.
Criteria : Author : "Nathalie,Tzourio-Mazoyer;Bernard,Mazoyer;Laurent,Petit;Fabrice,Crivello;Marc,Joliot;Emmanuel,Mellet;Laure,Zago;Gael,Jobard;Isabelle,Hesling", Publication type : "('ART')"
Number of occurrences founded : 149.
- Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents A Voxelwise and Genome-Wide Association Study
- Qiang Luo, Qiang Chen, Wenjia Wang, Sylvane Desrivières, Erin Burke Quinlan, Tianye Jia, Christine Macare, Gabriel H Robert, Jing Cui, Mickael Guedj, Lena Palaniyappan, Ferath Kherif, Tobias Banaschewski, Arun L W Bokde, Christian Büchel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Marie-Laure Paillère-Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H Fröhner, Michael N Smolka, Henrik Walter, Robert Whelan, Joseph H Callicott, Venkata S Mattay, Zdenka Pausova, Jean-François Dartigues, Christophe Tzourio, Fabrice Crivello, Karen F Berman, Fei Li, Tomáš Paus, Daniel R Weinberger, Robin M Murray, Gunter Schumann, Jianfeng Feng
- JAMA Psychiatry, 2019, 〈10.1001/jamapsychiatry.2018.4126〉
- What Are the Contributions of Handedness, Sighting Dominance, Hand Used to Bisect, and Visuospatial Line Processing to the Behavioral Line Bisection Bias?
- Audrey Ochando, Laure Zago
- Frontiers in Psychology, Frontiers, 2018, 9, 〈10.3389/fpsyg.2018.01688〉
- A Novel Three-Dimensional Electromagnetic Digital Actuator With 12 Discrete Positions
- Ajinkya Deshmukh, Laurent Petit, Muneeb Ullah Khan, Frédéric Lamarque, Christine Prelle
- IEEE/ASME Transactions on Mechatronics, Institute of Electrical and Electronics Engineers, 2018, 23 (4), pp.1653-1661
- Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging
- Xueqiu Jian, Claudia Satizabal, Albert Smith, Katharina Wittfeld, Joshua Bis, Jennifer Smith, Fang-Chi Hsu, Kwangsik Nho, Edith Hofer, Saskia Hagenaars, Paul Nyquist, Aniket Mishra, Hieab H.H. Adams, Shuo Li, Alexa Teumer, Wei Zhao, Barry Freedman, Yasaman Saba, Lisa Yanek, Ganesh Chauhan, Mark Van Buchem, Mary Cushman, Natalie Royle, R. Nick Bryan, Wiro Niessen, Beverly Windham, Anita Destefano, Mohamad Habes, Susan Heckbert, Nicholette Palmer, Cora Lewis, Gudny Eiriksdottir, Pauline Maillard, Rasika Mathias, Georg Homuth, Maria del C. Valdés-Hernández, Jasmin Divers, Alexa Beiser, Sönke Langner, Kenneth Rice, Mark Bastin, Qiong Yang, Joseph Maldjian, John Starr, Stephen Sidney, Shannon Risacher, Andre Uitterlinden, Vilmundur Gudnason, Matthias Nauck, Jerome Rotter, Pamela Schreiner, Eric Boerwinkle, Cornelia Van Duijn, Bernard Mazoyer, Bettina Von Sarnowski, Rebecca Gottesman, Daniel Lévy, Sigurdur Sigurdsson, Meike Vernooij, Stephen Turner, Reinhold Schmidt, Joanna Wardlaw, Bruce Psaty, Thomas Mosley, Charles Decarli, Andrew Saykin, Donald Bowden, Diane Becker, Ian Deary, Helena Schmidt, Sharon L.R. Kardia, M. Arfan Ikram, Stéphanie Debette, Hans Grabe, W.T. Longstreth, Sudha Seshadri, Lenore Launer, Myriam Fornage
- Stroke, American Heart Association, 2018, 〈10.1161/STROKEAHA.118.020689〉
- Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA consortium
- Xiang-Zhen Kong, Samuel R. Mathias, Tulio Guadalupe, David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, Clyde Francks
- Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2018, 115 (22), pp.E5154-E5163. 〈http://www.pnas.org/content/115/22/E5154〉. 〈10.1073/pnas.1718418115〉