Monoamines, Parkinson and Pain (page under construction)
ABY Franck (Post-doc) BONNEAU Juliane (Technician) BOUALI-BENAZZOUZ Rabia (Engineer) BROCHOIRE Louison (PhD student) DUVEAU Alexia (Post-doc) GRIVET Zoé (PhD student) LAVENU Leandre (PhD student) MAINGRET François (CNRS Researcher ) MOLPECERES-SIERRA Elba (PhD student) NAUDET Frédéric (Engineer) POLETTO Cristian (Assistant-engineer) VERBOVEN Aude (Technician) VIELLARD Juliette (Post-doc)
For any further information, please contact Dr Abdelhamid Benazzouz.
abdelhamid.benazzouz@u-bordeaux.fr
Research subject
Our team is particularly interested in the role of monoaminergic systems in the pathophysiology of non-motor symptoms of Parkinson’s disease.
We focus in particular on pain as a comorbidity of this neurodegenerative pathology but also as a pathology in its own. Indeed, chronic pain, whether or not associated with Parkinson’s disease, is a major public health problem and current treatments have little or no effect in relieving patients. Our objective is to better understand the plasticity that takes place in the dorsal horn of the spinal cord but also in the basal ganglia in order to allow the emergence of new effective therapies.
We use integrated approaches to study neural networks, combining classical electrophysiology techniques with the most recent optogenetic, chemogenetic and calcium imaging approaches. Finally, we are also developing new approaches to electrophysiologically recording neuronal activity in freely moving animals and deep brain stimulation to improve the analysis, understanding and treatment of these pathologies.
Latest publications
Criteria : Author : "Abdelhamid Benazzouz; 792175", Publication type : "('ART')"
Number of occurrences founded : 29.
- titre
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- auteur
- Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
- article
- Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
- identifiant
- hal-04018068
- titre
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- auteur
- Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
- article
- Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
- identifiant
- inserm-04012034
- titre
- Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
- auteur
- Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe de Deurwaerdere, Antoine Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves de Koninck, Pascal Fossat
- article
- Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abo0689⟩
- identifiant
- hal-03790498
- titre
- The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice
- auteur
- Damien Huzard, Miquel Martin, François Maingret, Jean Chemin, Freddy Jeanneteau, Pierre-François Méry, Pascal Fossat, Emmanuel Bourinet, Amaury François
- article
- Science Advances , 2022, 8 (26), pp.101-110. ⟨10.1126/sciadv.abo7566⟩
- identifiant
- hal-03714603
- titre
- Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor co-agonist D-serine
- auteur
- Glenn Dallérac, Xia Li, Pierre Lecouflet, Nadège Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, B Potier, David JG Watson, Staffan Schmidt, Grégoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin C Fone, Alain M Gardier, Thomas Freret, Angelo Contarino, Mark J Millan, Jean-Pierre Mothet
- article
- Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (23), pp.e2023750118. ⟨10.1073/pnas.2023750118⟩
- identifiant
- hal-03331836