Monoamines, Parkinson and Pain
BENAZZOUZ Abdelhamid, Director of Research INSERM FOSSAT Pascal, Prof. U. Bordeaux
MAINGRET François (CNRS Researcher ) BENAZZOUZ Rabia (Engineer) NAUDET Frédéric (Engineer) BONNEAU Julianne (Engineer / Technician) DUVEAU Alexia (Post-doctoral Student) RUELLE LE GLAUNEC Lucien (Post-doctoral Student ) VIELLARD Juliette (Post-doctoral Student ) BROCHOIRE Louison (PhD student) LAVENU Leandre (PhD student) MOLPECERES-SIERRA Elba (PhD student) VERBOVEN Aude (PhD Student )
For any further information, please contact Dr Abdelhamid Benazzouz.
abdelhamid.benazzouz@u-bordeaux.fr
Research subject
Our team is particularly interested in the role of monoaminergic systems in the pathophysiology of non-motor symptoms of Parkinson’s disease.
We focus in particular on pain as a comorbidity of this neurodegenerative pathology but also as a pathology in its own. Indeed, chronic pain, whether or not associated with Parkinson’s disease, is a major public health problem and current treatments have little or no effect in relieving patients. Our objective is to better understand the plasticity that takes place in the dorsal horn of the spinal cord but also in the basal ganglia in order to allow the emergence of new effective therapies.
We use integrated approaches to study neural networks, combining classical electrophysiology techniques with the most recent optogenetic, chemogenetic and calcium imaging approaches. Finally, we are also developing new approaches to electrophysiologically recording neuronal activity in freely moving animals and deep brain stimulation to improve the analysis, understanding and treatment of these pathologies.
Dernières publications
Criteria : Author : "Abdelhamid Benazzouz; 792175", Publication type : "('ART')"
Number of occurrences founded : 33.
- titre
- Brainstem serotonin amplifies nociceptive transmission in a mouse model of Parkinson’s disease
- auteur
- Zoé Grivet, Franck Aby, Aude Verboven, Rabia Bouali-Benazzouz, Benjamin Sueur, François Maingret, Frédéric Naudet, Thibault Dhellemmes, Philippe de Deurwaerdere, Abdelhamid Benazzouz, Pascal Fossat
- article
- npj Parkinson's Disease, 2025, 11 (1), pp.11. ⟨10.1038/s41531-024-00857-1⟩
- identifiant
- hal-04959441
- titre
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- auteur
- Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
- article
- Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
- identifiant
- hal-04018068
- titre
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- auteur
- Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
- article
- Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
- identifiant
- inserm-04012034
- titre
- A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- auteur
- Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne‐amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A Kienzler, Guillaume Sandoz
- article
- Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
- identifiant
- hal-04764950
- titre
- Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
- auteur
- Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe de Deurwaerdere, Antoine Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves de Koninck, Pascal Fossat
- article
- Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abo0689⟩
- identifiant
- hal-03790498