Research subject

Our research project aims to better understand the pathophysiology of Parkinson’s disease in order to improve the existing therapeutic approaches and to develop new therapies for the disease. Currently, we especially focus our work on the role of monoaminergic systems in the pathophysiology and therapy of Parkinson’s disease.

Nowadays, motors symptoms of Parkinson’s disease are better defined. We have recently shown the implication of monoamine depletion (noradrenaline, dopamine, serotonin) in the development of motor and non-motor deficits. The issue is now to study more precisely the role of the monoaminergic systems in the pathophysiology and treatments of Parkinson’s disease. Thus, we are working on five topics linked to this thematic:

  • Effects of combined monoamine cell degeneration on motor and non-motor functions.
  • Effects of combined monoamine cell degeneration on the neuronal activity of brain structures involved in motor and non-motor functions.
  • Impact of Noradrenaline and serotonin depletions on the therapeutic efficacy of anti-parkinsonian treatments.
  • Mechanisms of the deep brain stimulation of the subthalamic nucleus induced obesity (in collaboration with Daniela Cotta, Neurocentre Magendie, Bordeaux University).
  • Physiopathological study of alpha-synuclein model in rats : behavior, neurochemistry and electrophysiology.

L-DOPA is currently a reference treatment of Parkinson’s disease, but its effects are not well understood. Thanks to a neurochemical analysis, we are studying the mechanisms of action of this molecule in order to better understand its positive and negative effects. We are developing three topics:

  • Study of the mechanism of action of L-DOPA in-depth: role of serotonergic neurons and possible serotonergic strategies for ameliorating L-DOPA therapy.
  • Study of the action of L-DOPA on the activity of the basal ganglia.
  • Study of incorporation of L-DOPA into proteins.

Research axes

  • Study of the link between subthalamic nucleus oscillations and motor deficits.
  • Investigation of the consequences of monoamine modulation (dopamine, noradrenaline and serotonin) on motor and non-motor behaviors and on the neuronal activity of different brain structures implicated in these behaviors.
  • Study of the neurochemical consequences of L-Dopa and high frequency stimulation of the subthalamic nucleus in the context of Parkinson’s disease.

 

Complete bibliography >>>

Latest publications

Search Results --> Url version détaillée , Url version formatée
Criteria : Author : "Abdelhamid,Benazzouz; Philippe, De deurwaerdere", Publication type : "('ART')"
Number of occurrences founded : 44.

titre
Deleting Snord115 genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances
auteur
Virginie Marty, Jasmine Butler, Basile Coutens, Oumaima Chargui, Abdeslam Chagraoui, Bruno Guiard, Philippe de Deurwaerdère, Jérôme Cavaillé
article
Human Molecular Genetics, Oxford University Press (OUP), 2022, ⟨10.1093/hmg/ddac139⟩
identifiant
hal-03765098
titre
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
auteur
Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe de Deurwaerdere, Antoine Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves de Koninck, Pascal Fossat
article
Science Advances , American Association for the Advancement of Science (AAAS), 2022, 8 (30), ⟨10.1126/sciadv.abo0689⟩
identifiant
hal-03790498
titre
Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
auteur
Alexandra Gros, Léandre Lavenu, Jean-Luc Morel, Philippe de Deurwaerdère
article
International Journal of Molecular Sciences, MDPI, 2021, 22 (21), pp.11759. ⟨10.3390/ijms222111759⟩
identifiant
hal-03413891
titre
Simulated Microgravity Subtlety Changes Monoamine Function across the Rat Brain
auteur
Alexandra Gros, Léandre Lavenu, Jean-Luc Morel, Philippe de Deurwaerdère
article
International Journal of Molecular Sciences, 2021, 22, pp.11759. ⟨10.3390/ijms222111759⟩
identifiant
hal-03864127
titre
Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models
auteur
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc Do Rego, Jean-Claude Do Rego, Frédéric Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltête, Abdelhamid Benazzouz, Catherine Baugé, Jérôme Leprince, Abdel Elkahloun, Lee Eiden, Youssef Anouar
article
Redox Biology, Elsevier, 2021, 40, pp.101839. ⟨10.1016/j.redox.2020.101839⟩
identifiant
hal-03132187