Research subject

Neurological disorders are alterations of the central or peripheral nervous system caused by alterations in neuronal transmission or more global neuroinflammatory disturbances of local circuits involving glial cells.
The scientific goal of our team is to understand the contribution of neuronal versus inflammatory signaling in certain brain disorders such as amyotrophic lateral sclerosis (ALS), chronic inflammatory and neuropathic pain, and co-morbid pathologies such as attention-deficit/hyperactivity disorder (ADHD), and anxiety-related disorders.

Our research focuses on the involvement of three types of modulation of neuronal transmission:

1. Purinergic signaling and, more specifically, P2X ATP receptors capable of regulating the activity of neurons and microglia under normal and pathological conditions as well as developmental processes.
2. Peptidergic signaling involved in chronic pain processes and associated neuropsychiatric disorders. We are particularly interested in peptides of the relaxin family.
3. Inflammatory signaling and its consequences on the modulation of neuronal circuit activity

We combine cellular, anatomical, functional and behavioral approaches using different models, including cell cultures, the Xenopus model for neurodevelopmental studies, and various pharmacological, lesional, and transgenic mouse models.
We hope to define new innovative therapeutic strategies and cellular targets to cure these neurological disorders and neurodegenerative diseases.

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Latest publications

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Criteria : Author : "eric,boue-grabot; marc,landry", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 56.

titre
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
auteur
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
article
Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
identifiant
hal-04018068
titre
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
auteur
Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine Bertrand, Eric Boué-Grabot
article
Cellular and Molecular Life Sciences, 2022, 79 (8), pp.431. ⟨10.1007/s00018-022-04461-5⟩
identifiant
inserm-03727852
titre
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
auteur
Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe de Deurwaerdere, Antoine Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves de Koninck, Pascal Fossat
article
Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abo0689⟩
identifiant
hal-03790498
titre
Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction
auteur
Guillaume Beucher, Marie-Lise Blondot, Alexis Celle, Noemie Pied, Patricia Recordon-Pinson, Pauline Esteves, Muriel Faure, Mathieu Metifiot, Sabrina Lacomme, Denis Dacheux, Derrick Roy Robinson, Gernot Langst, Fabien Beaufils, Marie-Edith Lafon, Patrick Berger, Marc Landry, Denis Malvy, Thomas Trian, Marie-Line Andreola, Harald Wodrich
article
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (28), ⟨10.1073/pnas.2202370119⟩
identifiant
hal-03815383
titre
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
auteur
Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine S Bertrand, Eric Boué-Grabot
article
Cellular and Molecular Life Sciences, 2022, 79 (8), pp.431. ⟨10.1007/s00018-022-04461-5⟩
identifiant
hal-03727881