Research subject

Neurological disorders are alterations of the central or peripheral nervous system caused by alterations in neuronal transmission or more global neuroinflammatory disturbances of local circuits involving glial cells.
The scientific goal of our team is to understand the contribution of neuronal versus inflammatory signaling in certain brain disorders such as amyotrophic lateral sclerosis (ALS), chronic inflammatory and neuropathic pain, and co-morbid pathologies such as attention-deficit/hyperactivity disorder (ADHD), and anxiety-related disorders.

Our research focuses on the involvement of three types of modulation of neuronal transmission:

1. Purinergic signaling and, more specifically, P2X ATP receptors capable of regulating the activity of neurons and microglia under normal and pathological conditions as well as developmental processes.
2. Peptidergic signaling involved in chronic pain processes and associated neuropsychiatric disorders. We are particularly interested in peptides of the relaxin family.
3. Inflammatory signaling and its consequences on the modulation of neuronal circuit activity

We combine cellular, anatomical, functional and behavioral approaches using different models, including cell cultures, the Xenopus model for neurodevelopmental studies, and various pharmacological, lesional, and transgenic mouse models.
We hope to define new innovative therapeutic strategies and cellular targets to cure these neurological disorders and neurodegenerative diseases.

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Dernières publications

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Criteria : Author : "eric,boue-grabot; marc,landry", Laboratoire(Affiliation) : "UMR5293", Publication type : "('ART')"
Number of occurrences founded : 61.

titre
P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder
auteur
Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Ramy Adel, Marie Tuifua, Awatef Ali, Amina E Essawy, Sherine Abdel Salam, Walid Hleihel, Eric Boué-Grabot, Marc Landry
article
Frontiers in Pharmacology, 2024, 14, pp.1288994. ⟨10.3389/fphar.2023.1288994⟩
identifiant
hal-04372510
titre
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
auteur
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
article
Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
identifiant
hal-04018068
titre
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
auteur
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
article
Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
identifiant
inserm-04012034
titre
Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice
auteur
Damien Gilabert, Alexia Duveau, Sara Carracedo, Nathalie Linck, Adeline Langla, Rieko Muramatsu, Friedrich Koch-Nolte, F. Rassendren, Thomas Grutter, Pascal Fossat, Eric Boué-Grabot, Lauriane Ulmann
article
iScience, 2023, 26 (11), pp.108110. ⟨10.1016/j.isci.2023.108110⟩
identifiant
hal-04246591
titre
Purine Biosynthesis Pathways Are Required for Myogenesis in Xenopus laevis
auteur
Maëlle Duperray, Fanny Hardet, Elodie Henriet, Christelle Saint-Marc, Eric Boué-Grabot, Bertrand Daignan-Fornier, Karine Massé, Benoît Pinson
article
Cells, 2023, 12 (19), pp.2379. ⟨10.3390/cells12192379⟩
identifiant
hal-04225134