Research subject

Motion and emotion are intimately linked. The major goal of our research is to delineate the functions of dopamine in the “extended basal ganglia network” (EBG). EBG is a neural circuit controlling movement and emotional states (voluntary movement, associative learning, explorative behavior using processing of relevant sensory information, stress), but is also involved in neurological and psychiatric disorders (Parkinson’s disease, Huntington’s disease, anxiety). The objective of our team is to establish a base of knowledge to define therapeutic avenues to treat the symptoms of neurological and psychiatric diseases related to the dopaminergic system. We are particularly interested in the control of synaptic transmission and plasticity by dopamine.

We study these mechanisms at the synapse, cell, neuronal circuit and behavioral levels. We combine state-of-the-art technology, such as: in and ex vivo electrophysiology (coupled with cell identification after single cell labeling), intersectional viral approaches to identify (tracing), manipulate (optogenetics, chemogenetics) and record (endoscopic imaging & fiberphotometry) neuronal activity (calcium imaging) or dopamine release (dopamine sensor) in animals engaged in a behavioral task. Using those innovative neurotechniques we aim to uncover how defined subsets of neurons within the EBG encode aspects of motion and emotion.

 

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Latest publications

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Criteria : Author : "Jerome,Baufreton; François,Georges", Publication type : "('ART')"
Number of occurrences founded : 69.

titre
Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus
auteur
Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent
article
Current Neuropharmacology, In press, ⟨10.2174/1570159X21666230720121027⟩
identifiant
hal-04181821
titre
A non-canonical GABAergic pathway to the VTA promotes unconditioned freezing
auteur
Loïc Broussot, Thomas Contesse, Renan Costa-Campos, Christelle Glangetas, Léa Royon, Hugo Fofo, Thomas Lorivel, François Georges, Sebastian Fernandez, Jacques Barik
article
Molecular Psychiatry, 2022, ⟨10.1038/s41380-022-01765-7⟩
identifiant
hal-03806243
titre
Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons
auteur
Giulia Fois, Karl Bosque-Cordero, Rafael Vazquez-Torres, Cristina Miliano, Xavier Nogues, Carlos Jimenez-Rivera, Stéphanie Caille, François Georges
article
iScience, 2022, 25 (4), pp.104154. ⟨10.1016/j.isci.2022.104154⟩
identifiant
hal-03806295
titre
Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons
auteur
Giulia Fois, Karl Bosque-Cordero, Rafael Vazquez-Torres, Cristina Miliano, Xavier Nogues, Carlos Jimenez-Rivera, Stéphanie Caille, François Georges
article
iScience, 2022, 25 (4), pp.104154. ⟨10.1016/j.isci.2022.104154⟩
identifiant
hal-03805047
titre
Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons
auteur
Giulia Fois, Karl Bosque-Cordero, Rafael Vazquez-Torres, Cristina Miliano, Xavier Nogues, Carlos Jimenez-Rivera, Stéphanie Caille, François Georges
article
iScience, 2022, 25 (4), pp.104154. ⟨10.1016/j.isci.2022.104154⟩
identifiant
hal-04202886