Research subject

Our team develops new neuromodulation paradigms and neuroprosthetic systems for repairing or replacing circuit-level functions that get disrupted after neurological disorders or injury. Our research combines techniques from Neuroscience and Neuroengineering, in particular in vivo electrophysiology, signal processing, machine learning and control engineering.

Building upon previous experience of neuromodulation in the fields of epilepsy and spinal cord injury, we are now interested in expanding neuroprosthetic systems from motor to cognitive disorders. In particular, we aim at developing a large-scale brain network neuroprosthesis to restore memory after brain injury or neurodegenerative diseases such as Alzheimer’s disease (MEMOPROSTHETICS project, funded by an ERC Starting Grant). We are testing these principles in non-human primates trained to perform a visuo-spatial memory task.

Our approach uses intracranial multielectrode recordings of neuronal activity at various spatial scales such as local field potentials and electrocorticographic activity, combined with spatially, temporally and spectrally patterned multisite neurostimulation. This targeted stimulation aims at restoring the communication between remote brain areas which become functionally disconnected in memory disorders as a result of injury or neurodegeneration. By combining this neuromodulation approach with cognitive training protocols, we further aim at promoting neuroplasticity mechanisms and long-term improvements in cognitive functions.

 

This project has received the following funding / award:

– Young group leader chair of excellence, from the Région Nouvelle-Aquitaine and the University of Bordeaux as part of the Bordeaux Neurocampus initiative (2020-2023)

– ERC Starting Grant 2021 (MEMOPROSTHETICS project)

– ATIP-Avenir young group leader award, call 2021

 

Complete bibliography >>>

Dernières publications

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Criteria : Author : "Fabien Bertrand Paul,Wagner", Publication type : "('ART')"
Number of occurrences founded : 14.

titre
Neuroprosthetics: from sensorimotor to cognitive disorders
auteur
Ankur Gupta, Nikolaos Vardalakis, Fabien Bertrand Paul Wagner
article
Communications Biology, 2023, 6, ⟨10.1038/s42003-022-04390-w⟩
identifiant
hal-03947149
titre
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
auteur
Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura Mccracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien van den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri van de Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien Bertrand Paul Wagner, Jocelyne Bloch, Grégoire Courtine
article
Nature Medicine, 2022, 28 (2), pp.260-271. ⟨10.1038/s41591-021-01663-5⟩
identifiant
hal-03693436
titre
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
auteur
Jordan Squair, Matthieu Gautier, Lois Mahe, Jan Elaine Soriano, Andreas Rowald, Arnaud Bichat, Newton Cho, Mark Anderson, Nicholas James, Jerome Gandar, Anthony Incognito, Giuseppe Schiavone, Zoe Sarafis, Achilleas Laskaratos, Kay Bartholdi, Robin Demesmaeker, Salif Komi, Charlotte Moerman, Bita Vaseghi, Berkeley Scott, Ryan Rosentreter, Claudia Kathe, Jimmy Ravier, Laura Mccracken, Xiaoyang Kang, Nicolas Vachicouras, Florian Fallegger, Ileana Jelescu, Yunlong Cheng, Qin Li, Rik Buschman, Nicolas Buse, Tim Denison, Sean Dukelow, Rebecca Charbonneau, Ian Rigby, Steven Boyd, Philip Millar, Eduardo Martin Moraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Quentin Barraud, Erwan Bezard, Stéphanie Lacour, Jocelyne Bloch, Grégoire Courtine, Aaron Phillips
article
Nature, 2021, 590 (7845), pp.308-314. ⟨10.1038/s41586-020-03180-w⟩
identifiant
hal-03936914
titre
Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury
auteur
Emanuele Formento, Karen Minassian, Fabien Bertrand Paul Wagner, Jean Baptiste Mignardot, Camille Le Goff-Mignardot, Andreas Rowald, Jocelyne Bloch, Silvestro Micera, Marco Capogrosso, Grégoire Courtine
article
Nature Neuroscience, 2018, 21 (12), pp.1728-1741. ⟨10.1038/s41593-018-0262-6⟩
identifiant
hal-02508992
titre
Targeted neurotechnology restores walking in humans with spinal cord injury
auteur
Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot, Camille Le Goff-Mignardot, Robin Demesmaeker, Salif Komi, Marco Capogrosso, Andreas Rowald, Ismael Seáñez, Miroslav Caban, Elvira Pirondini, Molywan Vat, Laura Mccracken, Roman Heimgartner, Isabelle Fodor, Anne Watrin, Perrine Seguin, Edoardo Paoles, Katrien van den Keybus, Grégoire Eberle, Brigitte Schurch, Etienne Pralong, Fabio Becce, John O Prior, Nicholas Buse, Rik Buschman, Esra Neufeld, Niels Kuster, Stefano Carda, Joachim von Zitzewitz, Vincent Delattre, Tim Denison, Hendrik Lambert, Karen Minassian, Jocelyne Bloch, Grégoire Courtine
article
Nature, 2018, 563 (7729), pp.65-71. ⟨10.1038/s41586-018-0649-2⟩
identifiant
hal-02509201