Research subject

Our team is particularly interested in the role of monoaminergic systems in the pathophysiology of non-motor symptoms of Parkinson’s disease.

We focus in particular on pain as a comorbidity of this neurodegenerative pathology but also as a pathology in its own. Indeed, chronic pain, whether or not associated with Parkinson’s disease, is a major public health problem and current treatments have little or no effect in relieving patients. Our objective is to better understand the plasticity that takes place in the dorsal horn of the spinal cord but also in the basal ganglia in order to allow the emergence of new effective therapies.

We use integrated approaches to study neural networks, combining classical electrophysiology techniques with the most recent optogenetic, chemogenetic and calcium imaging approaches. Finally, we are also developing new approaches to electrophysiologically recording neuronal activity in freely moving animals and deep brain stimulation to improve the analysis, understanding and treatment of these pathologies.

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Dernières publications

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Criteria : Author : "Abdelhamid Benazzouz; 792175", Publication type : "('ART')"
Number of occurrences founded : 29.

titre
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
auteur
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
article
Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
identifiant
hal-04018068
titre
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
auteur
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael Kienzler, Guillaume Sandoz
article
Nature Communications, 2023, 14 (1), pp.1160. ⟨10.1038/s41467-023-36806-4⟩
identifiant
inserm-04012034
titre
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
auteur
Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe de Deurwaerdere, Antoine Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves de Koninck, Pascal Fossat
article
Science Advances , 2022, 8 (30), ⟨10.1126/sciadv.abo0689⟩
identifiant
hal-03790498
titre
The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice
auteur
Damien Huzard, Miquel Martin, François Maingret, Jean Chemin, Freddy Jeanneteau, Pierre-François Méry, Pascal Fossat, Emmanuel Bourinet, Amaury François
article
Science Advances , 2022, 8 (26), pp.101-110. ⟨10.1126/sciadv.abo7566⟩
identifiant
hal-03714603
titre
Sound radiation analysis with an enriched Timoshenko beam model based on second strain gradient theory
auteur
Guang Zhu, Abdelmalek Zine, Pascal Fossat, Mohamed Ichchou
article
Journal of Sound and Vibration, 2021, 509, pp.116249. ⟨10.1016/j.jsv.2021.116249⟩
identifiant
hal-03311607