Dopamine and neuronal assemblies
LADEVEZE Elodie (Assistant-engineer) LE BON-JEGO Morgane (MCU) DE MONTIGNY Jean (Post-doctoral reseacher) GLANGETAS Christelle (Post-doctoral researcher) GARCIA BAOS Alba (Post-doctoral researcher) GUILLAUMIN Adriane (Post-doctoral researcher) LEBOUC Margaux (Post-doctoral researcher) SIERRA Teresa (Post-doctoral researcher) ANDREJEW Roberta (PhD Student) BONAMY Léa (Phd Student) BRAINE Anaëlle (Phd Student) DE LAS HERRAS-GARCIA Laura (PhD Student ) ORTOLE Rodrigue (Phd Student) PERROT Emma (PhD Student ) SCHARNHOLZ Jakob (PhD Student) VILLACANA-MUNOZ Viviana (PhD Student )
For any further information, please contact
Dr Jérôme BAUFRETON
jerome.baufreton@u-bordeaux.fr
Dr François GEORGES
Research subject
Motion and emotion are intimately linked. The major goal of our research is to delineate the functions of dopamine in the « extended basal ganglia network » (EBG). EBG is a neural circuit controlling movement and emotional states (voluntary movement, associative learning, explorative behavior using processing of relevant sensory information, stress), but is also involved in neurological and psychiatric disorders (Parkinson’s disease, Huntington’s disease, anxiety). The objective of our team is to establish a base of knowledge to define therapeutic avenues to treat the symptoms of neurological and psychiatric diseases related to the dopaminergic system. We are particularly interested in the control of synaptic transmission and plasticity by dopamine.
We study these mechanisms at the synapse, cell, neuronal circuit and behavioral levels. We combine state-of-the-art technology, such as: in and ex vivo electrophysiology (coupled with cell identification after single cell labeling), intersectional viral approaches to identify (tracing), manipulate (optogenetics, chemogenetics) and record (endoscopic imaging & fiberphotometry) neuronal activity (calcium imaging) or dopamine release (dopamine sensor) in animals engaged in a behavioral task. Using those innovative neurotechniques we aim to uncover how defined subsets of neurons within the EBG encode aspects of motion and emotion.
Dernières publications
Criteria : Author : "Jerome,Baufreton; François,Georges", Publication type : "('ART')"
Number of occurrences founded : 77.
- titre
- A role for the subthalamic nucleus in aversive learning
- auteur
- Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
- article
- Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
- identifiant
- hal-04273150
- titre
- A role for the subthalamic nucleus in aversive learning
- auteur
- Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
- article
- Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
- identifiant
- hal-04272062
- titre
- Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus
- auteur
- Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent
- article
- Current Neuropharmacology, In press, ⟨10.2174/1570159X21666230720121027⟩
- identifiant
- hal-04181821
- titre
- Emotion in action: When emotions meet motor circuits
- auteur
- Anaelle Braine, François Georges
- article
- Neuroscience and Biobehavioral Reviews, 2023, 155, pp.105475. ⟨10.1016/j.neubiorev.2023.105475⟩
- identifiant
- hal-04311811
- titre
- The Subthalamic Nucleus: A Hub for Sensory Control via Short Three-Lateral Loop Connections with the Brainstem?
- auteur
- Racha Al Tannir, Arnaud Pautrat, Jérôme Baufreton, Paul Overton, Veronique Coizet
- article
- Current Neuropharmacology, 2023, 21 (1), pp.22-30. ⟨10.2174/1570159X20666220718113548⟩
- identifiant
- hal-03766484