Research subject

Motion and emotion are intimately linked. The major goal of our research is to delineate the functions of dopamine in the « extended basal ganglia network » (EBG). EBG is a neural circuit controlling movement and emotional states (voluntary movement, associative learning, explorative behavior using processing of relevant sensory information, stress), but is also involved in neurological and psychiatric disorders (Parkinson’s disease, Huntington’s disease, anxiety). The objective of our team is to establish a base of knowledge to define therapeutic avenues to treat the symptoms of neurological and psychiatric diseases related to the dopaminergic system. We are particularly interested in the control of synaptic transmission and plasticity by dopamine.

We study these mechanisms at the synapse, cell, neuronal circuit and behavioral levels. We combine state-of-the-art technology, such as: in and ex vivo electrophysiology (coupled with cell identification after single cell labeling), intersectional viral approaches to identify (tracing), manipulate (optogenetics, chemogenetics) and record (endoscopic imaging & fiberphotometry) neuronal activity (calcium imaging) or dopamine release (dopamine sensor) in animals engaged in a behavioral task. Using those innovative neurotechniques we aim to uncover how defined subsets of neurons within the EBG encode aspects of motion and emotion.

 

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Dernières publications

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Criteria : Author : "Jerome,Baufreton; François,Georges", Publication type : "('ART')"
Number of occurrences founded : 77.

titre
A role for the subthalamic nucleus in aversive learning
auteur
Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
article
Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
identifiant
hal-04273150
titre
A role for the subthalamic nucleus in aversive learning
auteur
Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie
article
Cell Reports, 2023, 42 (11), pp.113328. ⟨10.1016/j.celrep.2023.113328⟩
identifiant
hal-04272062
titre
Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus
auteur
Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent
article
Current Neuropharmacology, In press, ⟨10.2174/1570159X21666230720121027⟩
identifiant
hal-04181821
titre
Emotion in action: When emotions meet motor circuits
auteur
Anaelle Braine, François Georges
article
Neuroscience and Biobehavioral Reviews, 2023, 155, pp.105475. ⟨10.1016/j.neubiorev.2023.105475⟩
identifiant
hal-04311811
titre
The Subthalamic Nucleus: A Hub for Sensory Control via Short Three-Lateral Loop Connections with the Brainstem?
auteur
Racha Al Tannir, Arnaud Pautrat, Jérôme Baufreton, Paul Overton, Veronique Coizet
article
Current Neuropharmacology, 2023, 21 (1), pp.22-30. ⟨10.2174/1570159X20666220718113548⟩
identifiant
hal-03766484